Which enzyme seals the gaps between Okazaki fragments on the lagging strand?

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Multiple Choice

Which enzyme seals the gaps between Okazaki fragments on the lagging strand?

Explanation:
Okazaki fragments on the lagging strand are synthesized in pieces, leaving a nick between each fragment. DNA ligase is the enzyme that seals these gaps by forming a phosphodiester bond to join the adjacent fragments, creating a continuous DNA strand. While helicase unwinds the DNA, primase lays down RNA primers, and DNA polymerase extends from those primers, only ligase can close the backbone gaps. After primers are removed and the missing DNA is filled in, ligase glues the fragments together, finalizing the lagging-strand synthesis.

Okazaki fragments on the lagging strand are synthesized in pieces, leaving a nick between each fragment. DNA ligase is the enzyme that seals these gaps by forming a phosphodiester bond to join the adjacent fragments, creating a continuous DNA strand. While helicase unwinds the DNA, primase lays down RNA primers, and DNA polymerase extends from those primers, only ligase can close the backbone gaps. After primers are removed and the missing DNA is filled in, ligase glues the fragments together, finalizing the lagging-strand synthesis.

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