Which enzyme initiates replication by creating a replication fork that yields a Y-shaped structure?

Study for the Manor Preboards Module 2 Test. Use flashcards and multiple choice questions that include hints and explanations. Prepare thoroughly for your exam!

Multiple Choice

Which enzyme initiates replication by creating a replication fork that yields a Y-shaped structure?

Explanation:
Unwinding the DNA double helix to form a replication fork is accomplished by helicase. This enzyme uses energy from ATP to break the hydrogen bonds between base pairs, separating the two strands and creating the characteristic Y-shaped fork. That fork provides the single-stranded templates needed for DNA polymerases to synthesize new DNA in both directions from the origin. Primase then lays down RNA primers to start synthesis, DNA polymerase extends from those primers, and DNA ligase seals the final nicks. Without helicase, the strands stay paired and no replication fork forms, so replication can’t proceed.

Unwinding the DNA double helix to form a replication fork is accomplished by helicase. This enzyme uses energy from ATP to break the hydrogen bonds between base pairs, separating the two strands and creating the characteristic Y-shaped fork. That fork provides the single-stranded templates needed for DNA polymerases to synthesize new DNA in both directions from the origin. Primase then lays down RNA primers to start synthesis, DNA polymerase extends from those primers, and DNA ligase seals the final nicks. Without helicase, the strands stay paired and no replication fork forms, so replication can’t proceed.

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