What is the R group of Histidine?

Study for the Manor Preboards Module 2 Test. Use flashcards and multiple choice questions that include hints and explanations. Prepare thoroughly for your exam!

Multiple Choice

What is the R group of Histidine?

Explanation:
The side chain is an imidazole ring, a five-member aromatic heterocycle with two nitrogens. This ring gives histidine its ability to participate in acid–base chemistry near physiological pH (pKa about 6), allowing it to donate or accept a proton during enzyme reactions. The other options are different structures: indole is the ring found in tryptophan; a guanidino group is characteristic of arginine; and pyrrole is a simple five-member ring with one nitrogen, not the imidazole system in histidine. So the R group is the imidazole ring.

The side chain is an imidazole ring, a five-member aromatic heterocycle with two nitrogens. This ring gives histidine its ability to participate in acid–base chemistry near physiological pH (pKa about 6), allowing it to donate or accept a proton during enzyme reactions. The other options are different structures: indole is the ring found in tryptophan; a guanidino group is characteristic of arginine; and pyrrole is a simple five-member ring with one nitrogen, not the imidazole system in histidine. So the R group is the imidazole ring.

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